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PLT VASP/P2Y12

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Référence 7014
Statut CE
Echantillon 30 µl de sang total citraté
Quantité 10 tests
Détection Fluorescence
Application Pour le suivi des antagonistes spécifiques du récepteur plaquettaire à l’ADP (P2Y12)
Composition - Diluant. - PGE1 - PGE1 +ADP - Fixateur - Anticorps monoclonal anti VASP-P - Contrôle isotypique négatif - Réactif de révélation-FITC + contre-marqueur plaquettaire (CD61-PE).
L'échantillon sanguin est incubé parallèlement en présence de PGE1 seule ou de PGE1+ ADP. Aprés une perméabilisation cellulaire, la molécule VASP sous forme phosphorylée est marquée en immunofluorescence indirecte sans lavage par un anticorps monoclonal spécifique. L'analyse en cytométrie en flux , en double couleur , permet de comparer les deux conditions testées et d'évaluer, pour l'échantillon analysé, la capacité de l'ADP à inhiber cette phosphorylation.
Date Nom du document Taille du fichier Télécharger
01/03/2015 package insert PLT VASP P2Y12 - 478.72 Ko Télécharger
08/06/2010 Flyer PLT VASP P2Y12 - 592.82 Ko Télécharger
01/03/2018 package insert PLT VASP P2Y12 - 530.45 Ko Télécharger
Auteur Titre Année d'édition Revue
Bagoly Z. et al How to test the effect of aspirin and clopidogrel in patients on dual antiplatelet therapy?2016Platelets
Danese E. et al Relationship between pharmacokinetics and pharmacodynamics of clopidogrel in patients undergoing percutaneous coronary intervention: comparison between vasodilator-stimulated phosphoprotein phosphorylation assay and multiple electrode aggregometry2016J Thromb Haemost.
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Rollini F. et al Impact of timing from blood sampling to pharmacodynamic assessment on measures of platelet reactivity in patients treated with P2Y12 receptor inhibitors2016Thromb Haemost
Umemura K et alPharmacokinetics and pharmacodynamics of prasugrel in healthy Japanese subjects2016Drug Metab Pharmacokinet
Franchi F. et alPharmacodynamic Comparison of Prasugrel Versus Ticagrelor in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease The OPTIMUS (Optimizing Antiplatelet Therapy in Diabetes Mellitus)-4 Study2016Circulation
Umemura K et alPharmacokinetics and pharmacodynamics of prasugrel in healthy Japanese subjects2016Drug Metab Pharmacokinet
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Danese E. et alRelationship between pharmacokinetics and pharmacodynamics of clopidogrel in patients undergoing percutaneous coronary intervention: comparison between vasodilator-stimulated phosphoprotein phosphorylation assay and multiple electrode aggregometry2015J Thromb Haemost
Bonello L. et alTicagrelor increases endothelial progenitor cell level compared to clopidogrel in acute coronary syndromes: A prospective study2015Int J Cardiol
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Ferreiro JL et al.Impact of Prasugrel Reload Dosing Regimens on High On-Treatment Platelet Reactivity Rates in Patients on Maintenance Prasugrel Therapy2013J Am Coll Cardiol
Mazur P. et alImpaired responsiveness to clopidogrel and aspirin in patients with recurrent stent thrombosis following percutaneous intervention for peripheral arterial disease2013Platelets
Nakata T et alRelationship Between CYP2C19 Loss-of-Function Polymorphism and Platelet Reactivities With Clopidogrel Treatment in Japanese Patients Undergoing Coronary Stent Implantation2013Circ. J
Erlinge D. et al.Prasugrel 5-mg in the very elderly attenuates platelet inhibition but maintains noninferiority2013J Am Coll Cardiol
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Kim I.S. et al.Relation between the vasodilator-stimulated phosphoprotein phosphorylation assay and light transmittance aggregometry in 2013Am Heart J
El-Halabi MM et al.CYP2C19 Genetic Polymorphism, Rabeprazole and Esomeprazole Have no Effect on the Anti-Platelet Action of Clopidogrel2013J Cardiovasc Pharmacol.
Fontana P et al.Tailored Thienopyridine Therapy: No Urgency for CYP2C19 Genotyping2013J Am Heart Assoc.
Gurbel PA et al.The Influence of Smoking Status on the Pharmacokinetics and Pharmacodynamics of Clopidogrel and Prasugrel: The PARADOX Study2013J Am Coll Cardiol.
Gremmel T et al.Response to antiplatelet therapy is independent of endogenous thrombin generation potential2013Thromb Res.
Tello-Montoliu M. et al.Impact of aspirin dose on adenosine diphosphate-mediated platelet activity Results of an in vitro pilot investigation2013Thromb Haemost
Bonello L. et al.A randomized trial of platelet reactivity monitoring-adjusted clopidogrel therapy versus prasugrel therapy to reduce high on-treatment platelet reactivity2013Int J Cardiol.
Cuisset T. et alClinical Implications of Very Low On-Treatment Platelet Reactivity in Patients Treated With Thienopyridine2013J Am Coll Cardiol
Saucedo JF. et alDecrease in high on-treatment platelet reactivity (HPR) prevalence on switching from clopidogrel to prasugrel: Insights from the switching2013Thromb Haemost
Tantry U.S.Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding2013J Am Coll Cardiol.
Wang X.D et al. Modified clopidogrel loading dose according to platelet reactivity monitoring in patients carrying ABCB1 variant alleles in patients with clopidogrel resistance 2012Eur J Int Med
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Jeong YH. et al. High on-treatment platelet reactivity assessed by various platelet function tests: Is the consensus-defined cutoff of VASP-P platelet reactivity index too low?" 2012J Thromb Haemost
Frelinger A.L. et al, A Randomized, 2-Period, Crossover Design Study to Assess the Effects of Dexlansoprazole, Lansoprazole, Esomeprazole, and Omeprazole on the Steady-State Pharmacokinetics and Pharmacodynamics of Clopidogrel in Healthy Volunteers 2012J. Am. Coll. Cardiol.
Reny J.L. et al. Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis 2012J Thromb Haemost
Tello-Montoliu A.et al. Pharmacodynamic Effects of Prasugrel Dosing Regimens in Patients on Maintenance Prasugrel Therapy 2012J. Am. Coll. Cardiol.
Ferreiro J.L.et al. Impact of Adjunctive Cilostazol Therapy Versus High Maintenance Dose of Clopidogrel in Suboptimal Responders With Diabetes Mellitus 2012Rev Esp Cardiol.
Aradi D et al. Justification of 150 mg clopidogrel in patients with high on-clopidogrel platelet reactivity 2012Eur J Clin Invest.
Yokoi H et al.Pharmacodynamic assessment of a novel P2Y12 receptor antagonist in Japanese patients with coronary artery disease undergoing elective percutaneous coronary intervention2012Thromb Res
Bonello L. et alRelationship between post-treatment platelet reactivity and ischemic and bleeding events at one year follow-up in patients receiving prasugrel2012J Thromb Haemost
Liang Y et alRelation between clopidogrel active metabolite levels and different platelet aggregation methods in patients receiving clopidogrel and aspirin 2012J Thromb Thrombolysis
Bonello L. et al Biological efficacy of a 600 mg loading dose of clopidogrel in ST-elevation myocardial infarction 2012Thromb Haemost.
Bonello L. et alFactors associated with the failure of clopidogrel dose-adjustment according to platelet reactivity monitoring to optimize P2Y12-ADP receptor blockade2012Thromb Res
Erlinge D. et alReduction in Platelet Reactivity With Prasugrel 5 mg in Low-Body-Weight Patients Is Noninferior to Prasugrel 10 mg in Higher-Body-Weight Patients2012J Am Coll Cardiol
Suryadevara S. et alEffects of pioglitazone on platelet P2Y12-mediated signalling in clopidogrel-treated patientswith type 2 diabetes mellitus2012Thromb Haemost
Cuisset T. et alCYP2C19*2 and *17 Alleles Have a Significant Impact on Platelet Response and Bleeding Risk in Patients Treated With Prasugrel After Acute Coronary Syndrome2012 J Am Coll Cardiol Intv
Chang H et alModified Diadenosine Tetraphosphates with Dual Specificity for P2Y1 and P2Y12 are Potent Antagonists of ADP-induced Platelet Activation2012 J Thromb Haemost
Tello-Montoliu A et al Impact of renal function on clopidogrel-induced antiplatelet effects in coronary artery disease patients without diabetes mellitus2012J Thromb Thrombolysis
Morel et alThe extent of P2Y12 inhibition by clopidogrel in diabetes mellitus patients with acute coronary syndrome is not related to glycaemic control: roles of white blood cell count and body weight. 2012Thromb Haemost.
Yano H et alInfluence of Omeprazole and Famotidine on the Antiplatelet Effects of Clopidogrel in Addition to Aspirin2012Circ J.
Kalantzi KI et al.Clopidogrel differentially affects platelet-mediated thrombosis and inflammatory response in patients with acute coronary syndromes2011J Thromb Haemost.
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Ueno M et al. Functional profile of the platelet P2Y12 receptor signalling pathway in patients with type 2 diabetes mellitus and coronary artery disease2011Thromb Haemost
Angiolillo DJ et al.Impact of adjunctive cilostazol therapy on platelet function profiles in patients with and without diabetes mellitus on aspirin and clopidogrel therapy2011Thromb Haemost
Freynhofer MK et al.Multiple electrode aggregometry and vasodilator stimulated phosphoprotein-phosphorylation assay in clinical routine for prediction of postprocedural major adverse cardiovascular events2011Thromb Haemost
Mani H. et al.Platelet function testing in hirudin and BAPA anticoagulated blood2011Clin Chem Lab Med
Szymezak J. et al.High on-clopidogrel platelet reactivity: Genotyping can help to optimize antiplatelet treatment2011Thromb Res
Pettersen A. et al.The influence of CYP 2C19*2 polymorphism on platelet function testing during single antiplatelet treatment with clopidogrel2011Thrombosis Journal
Prüller F. et al.Low platelet reactivity is recoverd by transfusion of stored platelets: A healthy volunteer in vivo study2011J Thromb Haemost
Wang XD. et al.Modifying Clopidogrel Maintenance Doses According to Vasodilator-Stimulated Phosphoprotein Phosphorylation Index Improves Clinical Outcome in Patients With Clopidogrel Resistance2011Clin. Cardiol.
Frelinger A. et al.Clopidogrel pharmacokinetics and pharmacodynamics vary widely, independent of CYP2C19 polymorphisms, diet, smoking, proton pump inhibitors and other co-medications2011J. Am. Coll. Cardiol.
Angiolillo DJ et al.Impact of adjunctive cilostazol therapy on platelet function profiles in patients with and without diabetes mellitus on aspirin and clopidogrel therapy2011Thromb Haemost.
Storey RF et al.Earlier recovery of platelet function after discontinuation of treatment with ticagrelor compared to clopidogrel in patients with high antiplatelet responses2011J Thromb Haemost
Fontana P et al. Relationship between paraoxonase-1 activity, its Q192R genetic variant and clopidogrel responsiveness in the ADRIE study 2011J Thromb Haemost
Fernando H et al.Randomised Double Blind Placebo Controlled Crossover Study to Determine the Effects of Esomeprazole on Inhibition of Platelet Function by Clopidogrel2011J Thromb Haemost
Bonello L et al.High On-Treatment Platelet Reactivity After Prasugrel Loading Dose and Cardiovascular Events After Percutaneous Coronary Intervention in Acute Coronary Syndromes 2011J. Am. Coll. Cardiol.
Ferreiro JL et al.Pharmacodynamic evalutation of pentaprazole therapy on cloppidogrel effect2011Circ Cardiovasc Interv.
Ferreiro JL et al.Impact of Adjunctive Cilostazol Therapy Versus High Maintenance Dose of Clopidogrel in Suboptimal Responders With Diabetes Mellitus2011Rev Esp Cardiol.
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Tsoumani MEAntiplatelet Efficacy of Long-Term Treatment With Clopidogrel Besylate in Patients With a History of Acute Coronary Syndrome: Comparison With Clopidogrel Hydrogen Sulfate2011Angiology
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Delavenne X et al.Is there really a relationship between the plasma concentration of the active metabolite of clopidogrel and the results of platelet function tests?2010 J Thromb Haemost. 
Aradi D et al. Comparison of conventional aggregomerty with VASP for monitoring P2Y12-specifc platelet inhibition2010Platelets
Zighetti ML et al.Usefulness of a flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of patients with genetic defects of the platelet P2y12 receptor for ADP2010J Thromb Haemost. 
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Storey RF et al.Inhibitory Effects of Ticagrelor Compared With Clopidogrel on Platelet Function in Patients With Acute Coronary Syndromes The PLATO (PLATelet inhibition and patient Outcomes) PLATELET Substudy 2010J. Am. Coll. Cardiol.
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Bjellanda TW et al.Antiplatelet effect of clopidogrel is reduced in patients treated with therapeutic hypothermia after cardiac arrest2010Resuscitation
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Hogberg C. et al .Mild hypothermia does not attenuate platelet aggregation and may even increase ADP-stimulated platelet aggregation after clopidogrel treatment2009Thrombosis Journal
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Varenhorst C et al.Genetic variation of CYP2C19 affects both pharmacokinetic and pharmacodynamic responses to clopidogrel but not prasugrel in aspirin-treated patients with coronary artery disease2009Eur Heart J
Motovska Z et al. High loading dose of clopidogrel is unable to satisfactorily inhibit platelet reactivity in patients with glycoprotein IIIA gene polymorphism: a genetic substudy of PRAGUE-8 trial2009Blood Coagul Fibrinolysis
Michelson A. et alPharmacodynamic assessment of platelet inhibition by prasugrel vs. clopidogrel in the TRITON-TIMI 38 trial2009European Heart Journal
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Motovska Z et al. Clopidogrel resistance Live" - the risk of stent thrombosis should be evaluated before procedures2009Thrombosis J
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Gurbel PA et al.Omeprazole A Possible New Candidate Influencing the Antiplatelet Effect of Clopidogrel2008J. Am. Coll. Cardiol.
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Bonello L et al.Adjusted Clopidogrel Loading Doses According to VASP Phosphorylation Index Decrease Rate of Major Adverse Cardiovascular Events in Patients With Clopidogrel Resistance: A Multicentre Randomized Prospective Study2008J. Am. Coll. Cardiol.
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Umemura K et al,The common gene variants of CYP2C19 affect pharmacokinetics and pharmacodynamics to an active metabolite of clopidogrel in healthy subjects2008 J Thromb Haemost
Bonello L et al, A threshold of platelet reactivity for ischaemic events?2008Eur Heart J.
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Schäfer A et al.ADP-induced platelet aggregation frequently fails to detect impaired clopidogrel-responsiveness in patients with coronary artery disease compared to a P2Y12-specific assay2008Thromb Haemost
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Morel O et al.Residual prothrombotic status in low responder patients to clopidogrel identified by Vasodilator-Stimulated Phosphoprotein Phosphorylation (VASP) analysis?2008Thromb Haemost
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Cayla G et al.Flow cytometric assessment of vasodilator-stimulated phosphoprotein: Prognostic value of recurrent cardiovascular events after acute coronary syndromes2008Arch Cardiovasc Dis.
Aleil B et al.Ticlopidine could be an alternative therapy in the case of pharmacological resistance to clopidogrel: a report of three cases2007J Thromb Haemost
Angiolilo DJ et al.Randomized comparison of a high clopidogrel maintenance dose in patients with Diabetis mellitus and coronary artery disease2007Circulation
van Werkum et al.The flow cytometric VASP assay can be used to determined the effectiveness of clopidogrel in patients treated with Abciximab2007J Thromb Haemost
Cuisset T et al.Lack of association between the 807C/T polymorphism of glycoprotein Ia gene and post-treatment platelet reactivity after aspirin and clopidogrel in patients with acute coronary syndrome2007Thromb Haemost.
Mueller Tet al.Utility of whole blood impedance aggregometry for the assessment of clopidogrel action using the novel Multiplate® analyzer -comparison with two flow cytometric methods"2007Thromb Res
Cuisset T. et al. Role of the T744C polymorphism of the P2Y12 gene on platelet response to a 600-mg loading dose of clopidogrel in 597 patients with non-ST-segment elevation acute coronary syndrome2007Thromb Res
Bonello L et al.VASP phosphorylation analysis prior to percutaneous coronary intervention for exclusion of post-procedural major adverse cardiovascular events2007 J Thromb Haemost
Cattaneo M et al.Platelet P2 receptors: old and new targets for antithrombotic drugs2007Cardiovascular Therapy
Gurbel PA et al.Assessment of clopidogrel responsiveness : measurements of maximum platelet agreggation, final platelet agreggation and their correlation with Vasodilator stimulated phosphoprotein in resistant patients2007Thromb Res
Schumacher WA et al.Biomarker optimization to track antithrombotic and hemostatic effects of clopidogrel2007J Pharmacol Exp Ther.
De Gaetano and Cerletti. Platelet function, antiplatelet therapy and clinicla outcomes : to test or not to test ?2007J Thromb Haemost
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