Stability evaluation of a new synthetic Collagen Related Peptide (CRP-A) agonist compared to the equine fibrillar collagen type I-III
" Diagnosis of thrombopathies (inherited or acquired) are performed through platelet function tests (PFTs) using specific agonists targeting the major platelet receptors (PAR-1, P2Y1 & P2Y12, α"Diagnosis of thrombopathies (inherited or acquired) are performed through platelet function tests (PFTs) using specific agonists targeting the major platelet receptors (PAR-1, P2Y1 & P2Y12, α2A, GPVI, TxA2). While naturally occurring collagen can target multiple Gp receptors, CRP-A almost exclusively targets GPVI."
"The present study compares the stability of synthetic CRP-A to equine collagen at room temperature (RT), 4°C or after several freeze/thaw cycles. The agonists activities were evaluated in functional tests such as flow cytometry (FCM) or light transmission aggregometry (LTA)."
Les résultats démontrent que le CRP-A synthétique est un agoniste plaquettaire efficace, doté d'une forte activité et d'une excellente stabilité. Il représente une alternative pertinente au collagène d'origine animale et offre un intérêt clinique pour le diagnostic des anomalies plaquettaires et le suivi des thérapies antiplaquettaires.
